Carcinoma Mucoepidermoide de Glándulas Salivales Intraoral: Factores Clínicos y Patológicos e Inmunoexpresión de c-erbB-2 en 29 Casos. Vanessa Fátima. Abstract. AVILA, Rodolfo Esteban et al. Mucoepidermoid Carcinoma of Salivary Glands: Histological and Inmunohistochemical Prognostic Factors. Publisher: El propósito de este estudio es presentar la casuística del carcinoma mucoepidermoide de glándulas salivales de pacientes diagnosticados en el.

Author: Mumi JoJorg
Country: Japan
Language: English (Spanish)
Genre: Life
Published (Last): 14 May 2012
Pages: 209
PDF File Size: 10.4 Mb
ePub File Size: 12.9 Mb
ISBN: 459-4-29892-897-9
Downloads: 76532
Price: Free* [*Free Regsitration Required]
Uploader: Meztit

Our data suggest that carcinooma investigation is indeed warranted to better assess the role of c-erbB-2 immunoexpression in pathogenesis of mucoepidermoid carcinomas of salivary glands. Treatment and survival outcomes based on histologic grading in patients with head and neck mucoepidermoid carcinoma.

However, other studies reported a rare expression of c-erbB-2 on these tumors Kernohan et al. Mucoepidermoid carcinoma of minor salivary glands: HER2 expression in salivary gland carcinomas: Through a long follow-up period in present study we could highlight the relevance of primary anatomical site, tumor size and metastasis as useful prognostic factors that may affect survival in patients with a primary diagnosis of head and neck mucoepidermoid carcinomas.

The reactions were revealed by applying 0. Considering the results in the appraised sample, our findings suggest that some mucoepidermoid carcinoma overexpress c-erbB-2 independent of clinicopathological features such as patient age and gender and site or histological grades of the lesions.

For this study only the intraoral MEC surgically treated with adequate material for microscopic and immunohistochemical analysis corresponding to 29 cases were analyzed. Previous studies of c-erbB-2 expression in salivary gland carcinomas are sparse, comprise heterogeneous subtypes, and show contradictory results Locati et al. University of Sao Paulo, Brazil. Complementary studies to compare carbohydrates of the normal salivary glands must be carried out because subtle alterations in tumor cells glycosylation can influence their biological behavior.


Casilla D Temuco – Chile Tel.: Casilla D Temuco – Chile Tel.: Inmunostaining for ki67 were made. Surgical resection was performed in all patients. Histopathologic grading of salivary gland neoplasms.

Carcinoma mucoepidermoide de glándulas salivales en Brasil: relación clinicopatológica

All positive cases also expressed cytoplasmic staining. Different conclusions may be attributed to the varying techniques used, criteria applied to determine positive c-erbB-2 expression, the diversity of lesions and the limited number evaluated mucoepdermoide some studies. Cytoplasmic expression of c-erbB2 in non-small cell lung cancers. Evaluation of the immunohistochemical staining.

Surgical Pathology ofthe salivary glands. Although the latter may present myoepitelial derivation, carcinoma ex pleomorphic adenoma probably adquired a particular biological behavior in the longstanding process of malignant transformation. Besides, in the present study a standardized method was employed for evaluation of positivity.

We undertook this study to analyze the histological grade and proliferative potential as prognostic factors, important to guide the treatment and design recommendations, in a series of 13 patients who were treated for MEC of principal and accessory salivary glands between and Microscopically, most intraoral MEC mucowpidermoide classified mucoepidermoixe low grade of maligancy 27cases – The follow-up period in this study ranged from 6 to months median 65 monthsand the 5 and year OS rates were both Through a long follow-up period in present study was highlight the relevance of primary anatomical site, tumor size and metastasis as useful prognostic factors that may affect survival in patients with a primary diagnosis of head and neck mucoepidermoid carcinomas.

Growth Factors, 24 2: Coexpression of p53 and c-erbB-2 proteins is associated with histological type, tumour stage, and cell proliferation in malignant salivary gland tumours.

Intraoral mucoepidermoid carcinoma of salivary glands. Mucoepidermoid tumors of the salivary glands. Published works usually lose relevant survival information through time. All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License. R; Dempsey, R J.

  ASCE 74-2009 PDF

Carcinoma mucoepidermoide

Immunohistochemical study of c-erbB-2 oncoprotein overexpression in human major salivary gland carcinoma: Mucoepidermoid carcinoma of the mucoepidermoode and neck: Mucoepidermoid carcinoma of intraoral salivary glands.

This overexpression may be due to the process envolving histogenesis and celular differentiation. Immunoexpression of c-erbB-2 and p53 in benign and malignant salivary neoplasms with myoepithelial differentiation.

There have been suggestions that the overexpression of c-erbB-2 mucorpidermoide salivary gland tumors is related with histogenesis of these lesions Glisson et al.

Carcinoma mucoepidermoide

Jpn J Clin Oncol. Mucoepidermoid carcinoma of the salivary glands -clinical review of 42 cases. Mucoepidermoid carcinoma of the salivary glands. Oral Oncol, 41 1: Future investigations could benefit from this study, helping to provide further strategies for more efficient management of MECs.

The palate was the most commonly affected site, with 21 cases Data regarding the positivity for glandula on salivary gland tumors are very carcionma. Evaluation and application of grading criteria in cases. In situ intraductal carcinoma of the breast was used as a c-erbB-2 positive control and negative controls were obtained by the omission of the primary antibody.

Seifert G, Sobin LH. Mucoepidermoid carcinoma MEC is the most common epithelial neoplasm mucoepideermoide the salivary glands; the biological behavior relates to a histological grade of the tumor low, intermediate and high grade.