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This condition is rare and was detected from a thorough inspection of the vagina when sampling the cervix. Moreover, a higher rate of inflammatory reaction was found to be present in the CS compared to the SS, whereas more epithelial cells bt clear nuclear details were present in the SS compared with bfos CS Figure 2likely owing to the fact that these are living cells that are attached to the cervical surface, and if these are actively removed, their cytological characteristics will be more well-preserved at the time of fixation Figure 3.

A Resource Pack for Trainers. Nova, the authors concluded that the cervix should be ve at the discretion of the clinician.

One positive case detected in the CS was not detected in the SS. Am J Obstet Gynecol. All cases with abnormal previous cytology, hros of the colposcopy diagnosis, underwent biopsy.

The SS resulted in a higher proportion of adequate samples being obtained Based on our results herein, we believe that cervical samples containing CS are not optimal, as the rate of ASs is low. To date, no analysis on what the mucus contains from the cervix has been performed. Out of consecutive patients who attended our laboratory for cytology and colposcopy between June and March Sensitivity of cervical cytology is suboptimal, especially in developing countries such as Mexico, despite available guidelines aimed at improving this.

However, when the cervix is cleaned using a cytobrush, the abundance of the mucus becomes apparent, and these CS samples were found gineccologia have less epithelial cells and more inflammatory reactions than the samples obtained from the cleaned cervix.


An example of the amout of mucus retired. All CIN-positive cases detected in the CS samples and SS were confirmed by biopsy and p16 immunohistochemical staining, and were considered true positive cases.

In cytology cases of atypical squamous cells of undetermined significance ASC-US or in which a high-grade squamous intraepithelial lesion could not be excluded ASC-Hadditional slides were analyzed for p16 expression to confirm or rule out CIN.

P16 INK4a Immunohhistochemestry impreoves interobserver agreement in the diagnosis of cervical intraepithelial neoplasia. The quality of samples according to the Bethesda System, the presence of CIN, and inflammatory reactions were recorded.

Koss [ 19 ] answers this question by referring to some very early papers, including Sedlis et al. Results Of the cases, ASs were found in By excluding CS from cervical samples, the sensitivity could be improved and the false negative rate could be reduced.

Disclosure of conflict of interest None. Cervicovaginal cytology based on the Papanicolaou technique: Cases in which biopsy was not performed were considered as true negative based on a previous and actual negative cytology or previous colposcopy results that were considered obviously mistaken.

Int J Clin Exp Pathol. Conversely, the CS was in contact with the vaginal wall and contained diagnostic cells in this case, and the biopsy found a typical condyloma with koilocytes.

Cervical secretions CS are always present in variable proportions, and when cleaning the cervix, better samples may be obtained. Solomon D, Nayar R.

La crétinisation par la culture

The methods for obtaining samples have been described elsewhere [ 4 – 8 ]. Ginexologia cancer screening in the 21st century, is ginecologoa time to retire PAP Smear? Dysplastic cells of the same patient, in A from the Cs, with more inflammatory cells, and the nucleus of the atypical cells are note clearly seen. Materials and methods Subjects Out of consecutive patients who attended our laboratory for cytology and colposcopy between June and March Clinical and Laboratory Standards Institute.


When obtaining cervical samples, whether the samples are taken from the transformation zone and whether abnormal cells are missing must be considered. In cases of broos or if the SQCJ was not visible in endocervical canal with a very small orifice, two devices were used: Am J Surg Path.

Some cases appeared very clean even if the surface was covered with abundant transparent mucous; and hence, at first sight, some gynecologists or colposcopists may decide not to clean the surface.

Table 1 Sample characteristic and kind of inflammation detected in the histophatologycal analyze in CS and SS respectively. Procedure for removing the cervical mucus. If not cleaned, the mucus may prevent the instrument from obtaining cells from the cervical surface.

The sensitivities for CS and SS were There were no false positive results in the SS. If the CS is removed with an oversized or normal-sized cotton swab, it is likely that the swab touches the cervical surface and may result in some CIN cells being removed; and these would hence not be present in the clean, second sample SS. Author information Article notes Copyright and License information Disclaimer. The samples should be obtained by trained personnel, including gynecologists, and ideally, the sample should be taken from the transformation zone TZ [ 23 ].

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Ginecología de Novak

View of the mucus on the cervical surface. A biopsy was performed in cases, in which acetowhite imaging was seen; of these, 24 cases had a previous positive biopsy. Most patients were middle-class Caucasian or Hispanic women.